| # | Children | Name | Born | Died | Father | Mother |
| 1 | | | b. Abt 1726 | d. Aft 1745 | William R. Renfro, Sr. | Elizabeth Cheney |
| 2 | Yes | | b. 1727 | d. 11 Jul 1801 | William R. Renfro, Sr. | Elizabeth Cheney |
| 3 | Yes | | b. 2 Jan 1728 | d. 14 Jan 1824 | William R. Renfro, Sr. | Elizabeth Cheney |
| 4 | Yes | | b. Abt 1730 | d. Aft 1759 | William R. Renfro, Sr. | Elizabeth Cheney |
| 5 | | | b. 1730 | d. 2 Dec 1761 | William R. Renfro, Sr. | Elizabeth Cheney |
| 6 | Yes | | b. 14 May 1734 | d. 1 Sep 1830 | William R. Renfro, Sr. | Elizabeth Cheney |
| 7 | | | b. 1736 | d. Aft 1836 | William R. Renfro, Sr. | Elizabeth Cheney |
| 8 | Yes | | b. 1739 | d. 1818 | William R. Renfro, Sr. | Elizabeth Cheney |
| 9 | Yes | | b. 1740 | d. 1798 | William R. Renfro, Sr. | Elizabeth Cheney |
| 10 | | | b. 1741 | d. Aft 1741 | William R. Renfro, Sr. | Elizabeth Cheney |
| 11 | | | b. 1742 | d. Aft 1742 | William R. Renfro, Sr. | Elizabeth Cheney |
| 12 | Yes | | b. 1745 | d. Aft 1840 | William R. Renfro, Sr. | Elizabeth Cheney |